For people with arthritis, pain relief can be incomplete or short-lived even with treatment. Scientists at the University of ...

Chronic pain, including arthritis pain, affects more than one-third of U.K. adults. Current painkillers such as methotrexate and nonsteroidal anti-inflammatory drugs (NSAIDs) work by damping down the ...

A nerve protein called TRPM2 may help turn inflammation signals into pain, offering a possible future treatment target.

Brain preserved in formaldehyde. — Gaetan Lee (CC BY 2.0) Scientists have discovered a brain “pain switch” that prioritises survival needs over chronic suffering. This discovery could lead to new hope ...

When activated, this switch provides durable pain relief without affecting normal sensation or triggering reward pathways that can lead to addiction. "To our knowledge, this represents the world's ...

For the more than 50 million Americans living with chronic pain, the question has always been the same: why does it stay? A torn ligament heals. A surgical wound closes. Yet the pain persists, ...